Treatment of symptomatic epidermolysis bullosa simplex with botulinum toxin in a pediatric patient
نویسندگان
چکیده
EBS: epidermolysis bullosa simplex INTRODUCTION Botulinum toxin has been used to treat plantar blistering and pain in 7 epidermolysis bullosa simplex patients, includingone child,with excellent but transient success (Table I). Most of these patients were treated with abobotulinumtoxinA, including the indexed pediatric patient. We recently investigated the use of onabotulinumtoxinA to treat epidermolysis bullosa simplex (EBS) symptoms in a pediatric patient, making this successful treatment unusual. Dose equivalence ranging from 2:1 to 4:1 abobotulinumtoxinA to onabotulinumtoxinA, respectively, has been suggested for the treatment of glabellar wrinkles and axillary hyperhidrosis, but further evidence is needed to determine the appropriate dose for management of EBS symptoms in both pediatric and adult patients. Additionally, the relative importance of the toxin’s role inhyperhidrosis reductionandon localneurotransmitter release in neuropathic pathways deserves exploration.
منابع مشابه
Botulinum toxin in the treatment of sweat-worsened foot problems in patients with epidermolysis bullosa simplex and pachyonychia congenita.
BACKGROUND Painful foot blistering is a common problem in patients with epidermolysis bullosa simplex (EBS) and pachyonychia congenita (PC). Hyperhidrosis, a condition which can be effectively blocked by plantar injections of botulinum toxin (Btx), often exacerbates the blistering. OBJECTIVES A retrospective evaluation of the effects of Btx injections in 14 patients with EBS and PC with foot ...
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عنوان ژورنال:
دوره 2 شماره
صفحات -
تاریخ انتشار 2016